Stroke

Staff

  • Prof. Dr. Werner Z’Graggen (Leiter der Forschungsgruppe "Subarachnoidalblutung / Stroke")
  • Prof. Dr. Claudio L. Bassetti (Direktor Universitätsklinik für Neurologie, Inselspital Bern)
  • PD Dr. Marie-Luise Mono
  • PD Dr. Hakan Sarikaya
  • Dr. Rupa Balasubramaniam
  • Dr. Rebekka Kurmann
  • Dr. Anne Broeg
  • Dr. Aikaterini Galimanis
  • Dr. Barbara Goeggel-Simonetti
  • Dr. Mirjam Heldner
  • Prof. Dr. Heinrich Mattle
  • Marianne Kormann
  • Andrea Surtmann

Research focuses

  • Diagnosis and treatment of patients with cerebrovascular disorders
  • Neurological emergencies
  • Translational cerebrovascular research
  • Ischemic stroke
  • Intracerebral hemorrhage
  • Blood pressure and stroke
  • Diagnosis and treatment of extra- and intracranial dissections
  • Decompressive craniectomy
  • Outcome research
  • Stroke in children and young adults
  • Headache and vertigo in patients with  neurological emergencies

Methods

  • Randomised controlled trials
  • Prospective registries
  • Biomarkers
  • Correlation of clinical findings and imaging

Short description

Development of new management approaches in acute stroke therapy has been the main focus of the Stroke Research Group (SRG) for the last 20 years. Currently the main challenges in the field of acute ischemic stroke therapy are the improvement of patient management and patient selection, the optimization of multimodal brain and vessel neuroimaging, and the increase of patients who can benefit from reperfusion therapies. Several ongoing and planned research projects aim at improving patient selection, acute stroke management and predicting prognosis and complications. The use of multimodal imaging including penumbra imaging, analysis of collaterals, visualisation of small thrombi and analyses of intravenous and intra-arterial biomarkers using a proteomics approach are promising tools to reach these goals.

There are several ongoing clinical trials: The international  randomized controlled multicentre SWITCH trial (www.switch-trial.ch) funded by the Swiss National Science Foundation and initiated by the department of neurosurgery and the department of neurology assesses whether decompressive surgery and best medical treatment in patients with spontaneous intracerebral hemorrhage will improve outcome as compared to best medical treatment alone. A randomized study funded by the Swiss National Science Foundation analyses the effect early treatment of sleep apnea with continues positive airway pressure (CPAP) in acute ischemic stroke patients and the effects of sleep apnea and other sleep disorders on long term outcome of stroke. An ongoing multidisciplinary Special Program University Medicine (SPUM) funded by the SNF focusses on pathogenesis, multimodalimaging and treatment of cervical artery dissection.  Further studies on improving treatment of patients with an acute ischemic stroke are currently under review. Furthermore, the SRG participates in investigator and non-investigator initiated trials such as TICH2, NAVIGATE ESUS, SORATES, TOACT, etc. The SRG works in close cooperation with the CTU Bern, the Neuro Clinical Trial Unit, the Center for Experimental Neurology (ZEN) and the Neuroinfection Laboratory at the Institute for Infectious Diseases, University of Bern.