Clinical and experimental (animal) sleep and neurology research
Research group leader
- Name / Titel
- Prof. Dr. med. Claudio Bassetti
- +41 31 632 30 66
- Laura Facchin, Msc.
- Armand Mensen, PhD
- Simone Duss, PhD
- Corina Gorban, Dr. med.
- Doris Kuen, Dr. med.
- Thomas Horvath, Dr. med.
- Ulf Kallweit, Dr. med.
- Frederic Zubler, Dr. med.
- Markus Schmidt, Dr. med.
- Diagnosis and therapy of sleep-wake disorders
- Pathophysiology of narcolepsy, neurogenic hypersomnia and other neurological sleep disorders
- Investigation of the pathogenesis of sleep associated breathing disorders and their influence on the prevalence and rehabilitation of stroke.
- Role of sleep for neuroplasticity and recovery following stroke
- Molecular biological methods
- Optogenetic and in vivo electrophysiology
Our research group combines clinical and basic research in order to get a better understanding of neuronal circuits that underlie sleep-wake regulation and to investigate the function of sleep during recovery from stroke and other neurological diseases. The primary objectives of some of the current projects are:
- To evaluate whether an immediate onset of Adaptive Servo-Ventilation (ASV) treatment in stroke patients with severe Sleep Disordered Breathing has a favorable effect on infarct growth.
- To assess the long-term outcomes after stroke in relation to the presence of sleep disorders.
- To measure alterations in electrical brain activity as well as brain connectivity changes in stroke patients and to correlate the quality of sleep with the respective rehabilitation outcome.
- To promote a positive effect on the motor activity previously affected by stroke through optogenetic induction of sleep oscillation in animal model.
- To identify an autoreactive T cell response against hypocretin in human narcolepsy.