EEG/Epileptology
Research group leader
- Name / Titel
- Prof. Dr. med., Dr. sc. nat. Kaspar Schindler
- Funktion
- Chefarzt, Stv. Klinikdirektor, Leiter Schlaf-Wach-Epilepsie Zentrum (SWEZ), Leiter NeuroTec sitem
- kaspar.schindler@insel.ch
- Phone
- +41 31 632 30 54
Short description
The main goal of our research is to better understand seizure dynamics. Seizure dynamics denotes how seizures begin, how they propagate and how they terminate. We study seizure dynamics by combining visual and quantitative EEG analysis. We have successfully applied different mathematical methods such as random matrix theory, graph theory, symbolic dynamics and hyperdimensional computing. The goal is to identify the patterns of electrical brain activity that have to be stabilized or suppressed - by pharmacological and non-pharmacological interventions - to either prevent or abort epileptic seizures.
More recently – and promoted by the newly established NeuroTec center at sitem-insel - we have started to test novel devices that enable the transfer from a hospital- to an outpatient-centric neurology. To this end we collaborate with research organizations and industrial partners to develop energy-efficient and robust methods for the analysis of digital biomarkers of epilepsy and sleep.
Research focus
- Late(r)-onset epilepsy
- Seizure dynamics
- Digital biomarkers of epilepsy and sleep
Ongoing projects
- eeGPT: Analysing Electroencephalograms with Generative Pre-trained Transformers (SNF)
- Long-term EEG monitoring during sleep for late(r) onset epilepsy (BMCC)
Key Publications
- Carzaniga FS, Hersche M, Schindler KA, Rahimi A. A Composable Channel-Adaptive Architecture for Seizure Classification. IEEE J Biomed Health Inform. 2026 Jan;30(1):279-291. doi: 10.1109/JBHI.2025.3587103. PMID: 40633043.
- Yilmaz G, Seiler A, Chételat O, Schindler KA. Ultra-Long-Term-EEG Monitoring (ULTEEM) Systems: Towards User-Friendly Out-of-Hospital Recordings of Electrical Brain Signals in Epilepsy. Sensors (Basel). 2024 Mar 14;24(6):1867. doi: 10.3390/s24061867. PMID: 38544134; PMCID: PMC10975815.
- Hanke JM, Schindler KA, Seiler A. On the relationships between epilepsy, sleep, and Alzheimer's disease: A narrative review. Epilepsy Behav. 2022 Apr;129:108609. doi: 10.1016/j.yebeh.2022.108609. Epub 2022 Feb 14. PMID: 35176650.
- Schindler KA, Rahimi A. A Primer on Hyperdimensional Computing for iEEG Seizure Detection. Front Neurol. 2021 Jul 20;12:701791. doi: 10.3389/fneur.2021.701791. PMID: 34354666; PMCID: PMC8329339.
Funding
- Swiss National Science Foundation (Kaspar Schindler)
- Bern Medtech Collaboration Call (BMCC)