Neuroimmunology/Multiple sclerosis

Research group leader

Staff

  • Dr. med. Anke Salmen
  • Dr. med. Robert Hoepner
  • Dr. med. Sandra Bigi
  • Dr. Lisa Schrewe
  • Dr. Kirsten Guse
  • Maud Bagnoud (PhD Student)
  • Saskia Steinheimer (Research Fellow)
  • Karin Streit (Study nurse)
  • Dr. Noemi Hiroshige (Study nurse)

Research focuses

  • Molecular surrogate marker/biomarker in neuroimmunological/neurodegenerative diseases
  • Therapy monitoring/risk stratification during therapy
  • Epidemiology, pharmacogenetics
  • Glial/neural immuno-biology
  • Animal models for degenerative diseases of the nervous system
  • Clinical studies
  • Disability measurement with modern para-clinical methods
  • Therapy studies

Methods

  • Murine animal model of MS: experimental autoimmune encephalomyelitis (EAE)
  • Experimental stroke (medial cerebral artery occlusion)
  • Histological and functional analyses in the context of animal models
  • Primary human cells and tissue/biological samples (peripheral immune cells, glial cells, CSF ): in vitro and ex vivo studies
  • Para-clinical/electrophysiological methods for detection of neurological disability in patients

Short description

The recently founded research group “Neuroimmunology/MS” combines basic research with translational and clinical approaches. We are particularly interested in the mechanisms of the autoimmune inflammatory responses of the nervous system in vitro, in animal models and in human biological samples with a special focus on glial and T-cell biology. The identification of potential molecular and clinical markers for detection of disease progression and the assessment of the benefit-risk profile under immunotherapy also follows a translational approach with biological samples from different clinical studies.